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Las revisiones Cochrane se revisan regularmente y se actualizan si es necesario. Non-steroidal anti-inflammatory drugs NSAIDs have been widely used as a pharmacologic treatment to relieve pain for patients with OA of the hip. To review all randomized trials of analgesics and anti-inflammatory therapy in osteoarthritis OA of the hip. Reference lists of all trials were also manually searched.
The trials selected for inclusion were identified by one reviewer TT and rechecked by a second MH. Qualitative assessments were performed using a quality scoring system designed for NSAID trials in rheumatoid arthritis. Both the design and analysis aspects of the trials were evaluated, each aspect being rated on a scale of 0 to 8. A quantitative method, which calculates the ratio of improvement produced by one NSAID to that produced by another, was used to rate the relative efficacy of different NSAIDs with respect to pain relief.
Toxicity comparisons were made according to the reviewer findings. All quality assessments were carried out independently by two reviewers TT, BS. A consensus was reached on discrepancies. Forty-three trials were identified, and of these, 39 evaluated NSAIDs, while four evaluated only analgesics.
The median design and analysis scores were two and four respectively. Of these, indomethacin was rated more effective in five of its seven comparisons, but more toxic in seven of 12 comparisons. Of the 43 RCTs identified only 17 had statistical data available for future pooling for this meta-analysis.
In the case where data was missing, authors of the trials will be contacted for inclusion of data in future reviews. NSAID trials in patients with OA of the hip appear to be weakened by the lack of standardization of case definition of OA, and also by the lack of standardization of outcome assessments.
Oxford, Update Software Ltd. Traducida de The Cochrane Library, Issue. Conclusiones de los revisores: