landerlan.netOntem quinta fez 21 dias da ultima dura! To report a case of symptomatic hypogonadism induced by the abuse ciclo stanozolol relato multiple steroid preparations that was subsequently reversed by clomiphene. University-affiliated andrology practice within family practice clinic. Clomiphene citrate, mg challenge for 5 days, followed by treatment at same dose for 2 ciclo stanozolol relato. Reversal of symptoms, normalization of T levels with LH surge, restoration of pituitary-gonadal axis.
INSPIRANDO o Winstrol, antes e depois fotos & Histórias de sucesso
Ontem quinta fez 21 dias da ultima dura! To report a case of symptomatic hypogonadism induced by the abuse of multiple steroid preparations that was subsequently reversed by clomiphene. University-affiliated andrology practice within family practice clinic. Clomiphene citrate, mg challenge for 5 days, followed by treatment at same dose for 2 months. Reversal of symptoms, normalization of T levels with LH surge, restoration of pituitary-gonadal axis. Clomiphene citrate is used typically in helping to restore fertility in females.
This represents the first case report of the successful use of clomiphene to restore T levels and the pituitary-gonadal axis in a male patient. The axis was previously shut off with multiple anabolic steroid abuse.
A year-old patient presented with severe depression and loss of libido and energy. He admitted to the use of steroids for bodybuilding purposes for several months. He had obtained nandrolone decanoate, deca Durabolin, primobolan depot, and Winstrol from a foreign country without a prescription. While showering, he noticed that his testicles were gradually shrinking, despite a more muscular body.
He does not report anosmia or any childhood orchitis. There was no history of galactorrhea or gynecomastia. There was no family history of hypogonadism. He had no hypospadias nor abnormalities in the epididymis. There was no goiter, gynecomastia, or visual field defects.
Muscle strength in all four limbs was grade 5 in both flexor and extensor groups. The androgen decline in aging male A.
For standardization purposes, blood work was done at 9. Free and total Ts were measured by radioimmunoassay methods. Magnetic resonance imaging did not show any abnormality in the pituitary area. Cortisol and thyroxine were also in the normal ranges.
Sperm samples were not collected as the patient declined. Total T levels rather than free or bioavailable T were used for follow-up. He was challenged with mg of clomiphene citrate for 5 days. The patient reported better moods and return of libido and energy, but still continued on his antidepressant.
The patient was followed up, and 2 months after clomiphene citrate challenge, he had a relapse of symptoms including tiredness and loss of libido.
A decision was made to continue treatment with clomiphene citrate for 2 months. The magnetic resonance imaging of the pituitary was repeated and remained normal. Symptoms resolved and the patient continues to be followed up. Clomiphene citrate is an orally administered, nonsteroidal ovulatory drug typically used in female infertility management.
It has both estrogenic and antiestrogenic properties. Clomiphene citrate initiates a series of endocrinologic events that cause a gonadotropin surge, which in turn causes an increase in steroidogenesis. Clomiphene citrate is thought not to have any inherent androgenic or anti-androgenic effect.
In this case, we were challenging the pituitary gland to produce a surge of gonadotropins to help restore function to the Leydig cells to produce T. Clomiphene citrate has been shown to increase T levels in both normal and impotent hypogonadal men probably reflecting the primacy of estrogen over T in the feedback regulation of male gonadal function. In a small, double-blind, placebo-controlled, crossover study of clomiphene against placebo in impotent men with secondary hypogonadism, there was a significant rise of LH, FSH, and T with clomiphene .
However, the study in these 17 men did not reveal any improvement of sexual function as measured with questionnaires and penile tumescence and rigidity testing. Another study investigated the hormonal response to clomiphene in alcoholics with hypogonadism  and found that clomiphene can increase androgens and estrogens.
The rise in estrogens was thought to be due to peripheral conversion of androgens to estrogens. Paradoxically, one study failed to show that clomiphene could restore pituitary testicular responsiveness in hypogonadotrophic hypogonadism but succeeded with human chorionic gonadotropin .
Clomiphene citrate has been used successfully in the treatment of idiopathic hypogonadotrophic hypogonadism induced by excessive exercise such as marathon running . In that case report, reestablishment of the physiologic hypothalamic-pituitary-gonadal axis with the return of normal T and gonadal function was achieved with clomiphene citrate 50 mg, 2 times per day over 5 months.
In our case, the reestablishment of eugonadal status was achieved with just a short challenge of clomiphene citrate mg over 2 weeks, but the patient relapsed. He needed a longer course of 2 months of clomiphene citrate to maintain eugonadal status.
Both cases, including ours, suggest that early intervention with clomiphene can restore the hypothalamic-pituitary-gonadal axis. We are still continuing to follow up our patient to establish long-term effects. The patient did not suffer from any hot flashes or other side effects from clomiphene citrate.
There have been no previously documented cases of clomiphene citrate improving exogenous steroid-induced testicular failure. The mechanism of initial testicular failure could be due to the suppression of LH due to the use of exogenous steroids, which in turn leads to decreased T levels. We postulate that clomiphene citrate can reestablish the axis even after steroid abuse has initially shut down the axis. It can induce the gonadotropin surge, initiate T levels to increase, and improve gonadal function and reverse symptoms.
This was possible in this case as the patient was relatively young and presumably had a more elastic axis. I am sure that a healthy man at any age can enhance testosterone.
I am not sure that it will do much for his libido and sexual function. I have tried a good number of hormonal supplements, and, based on my own experience and the scientific studies of others, I would say that it's not the way to go for sexual enhancement. While the dopamine route is not perfect either, medications such as bromocriptine at least have a measurable effect on sexual parameters if they are applied in the correct manner.
For the whole concept of it, I believe that matters other than supplying hormones or precursors should be emphasized. All hormone supplementation has not been shown to enhance the sexuality of basically healthy men. And enhancing sexuality would be my primary aim anyway. On the other hand, clomiphene citrate Clomid results in a character modification that I judge to be testosterone-driven. The clomiphene citrate stimulates the hypothalamus in a manner that, several steps downwards, results in higher testosterone levels.
I have also experimented with tribulus terrestis and tongkat ali, both herbs that are said to increase testosterone levels on a pathway similar to clomiphene citrate. I both cases, I feel the testosterone by becoming aggressive more easily.
Upon being provoked for example in road traffic I could spend minutes on imagining how I would maltreat a fellow driver who obstructed my path. I'd cut his ears, shoot his kneecaps, smash his balls, and drown him in a bathtub of human excrements. But do I want to become more aggressive? I'm on the search for real great sex.
I'm not a boxer or race driver, both of whom probably need aggressiveness to increase their chances of winning. Nor am I a body builder who would benefit from the anabolic component of an increased testosterone level. Sadly enough, the character modification I had in mind a general enhancement of libido and sexual performance did not occur on any testosterone enhancement schedule.
I, for myself, have to make sense of my personal experience with testosterone-enhancing medications, especially when comparing them with scientific information on the same topic. My current hypothesis not a theory I would have invented myself is that in the hormonal system, testosterone levels are not the crucial factor for enhanced libido and sexual performance.
You probably have to have the appropriate receptor sites for the pro-sexual effect of testosterone, and the receptor sites have to be activated. Apart from trying to be a good lay man, I'm also a layman. And like most laymen studying the endocrine system, I have initially strongly focused on hormones, and neglected the importance of receptors.
However, hormones exert their effects not just on tissue of any kind but only on tissue that has a chemical surface which is receptive to the hormone.
I assume that the effects of testosterone on libido and sexual performance are strongly correlated to certain receptor tissue in the brain for the libido and the reproductive organ for erections.
If you want to enhance, you will have to enhance both, hormones and receptor tissue. Testosterone can only have a pro-libido and pro-sexual-performance effect if there are specific tissue receptors where it can dock on.
On other tissue, testosterone has no effect. As far as I understand it, I and probably most other men don't suffer from a lack of aggression receptor sites that can be influenced by increasing testosterone. With testosterone receptor sites for sexual prowess, however, I seem to have a number of receptor sites that largely correlates to my own testosterone production.
For a sexual effect from enhancing testosterone, both would have to be increased: Sadly enough, I have not come across any medication that claims to increase the number of sexual testosterone receptor sites. PO galera, fiquei na duvid agr Faloe a pura verdade Me mostre ondse temos pesquisas q deve-se fazer frontloading?? Os textos que coloque eram apenas para que vcs pudessem ler e se interar mais com os relatos e estudos sobre a droga You need to be a member in order to leave a comment.
Sign up for a new account in our community. Already have an account? Relato uso de Clomid Rate this topic 1 2 3 4 5. Posted May 17, Share this post Link to post Share on other sites. Por isso que nao recomendo frontloading com clomid Fertil Steril Jan;79 1: