EliteFitness.com Bodybuilding ForumsThis dickersonross steroids the normal trade-off when it comes to the use of anabolic steroids, or almost anything in this world. This is why anabolic steroids hold such a wide array of application in science and medicine, which can be attributed to their diverse governance on the different systems of the body. This was one of the original goals of the anabolic steroid development boom of the s. Although no perfect anabolic steroid was ever created, science did come very close with the development of a select few anabolic steroids, such as Anavar Oxandrolone. Regardless, the nature of anabolic steroids is such that do anabolic steroids increase white blood cell count anabolic tissue building effects cannot be completely separated from the androgenic masculinizing effects, as the two are intrinsically intertwined.
Effects Of Steroids - Muscle Growth, Side Effects, Fat Loss & Usage
This is the normal trade-off when it comes to the use of anabolic steroids, or almost anything in this world. This is why anabolic steroids hold such a wide array of application in science and medicine, which can be attributed to their diverse governance on the different systems of the body. This was one of the original goals of the anabolic steroid development boom of the s.
Although no perfect anabolic steroid was ever created, science did come very close with the development of a select few anabolic steroids, such as Anavar Oxandrolone. Regardless, the nature of anabolic steroids is such that the anabolic tissue building effects cannot be completely separated from the androgenic masculinizing effects, as the two are intrinsically intertwined.
Only a distinct distancing of the two might be possible to a certain extent, but never a total elimination or separation of them. There are many different anabolic steroid analogues and derivatives, and they are derived from one of three primary hormones that are naturally created and found within the human body.
Essentially, all anabolic steroid derivatives are derivatives of Testosterone, as Testosterone is in fact the precursor for Nandrolone and Dihydrotestosterone. Without Testosterone, either of the latter two would exist. However, once isolated in a laboratory, Nandrolone and Dihydrotestosterone themselves can be directly modified at their chemical structures in order to create an analogue or derivative of whichever hormone is being modified known as the parent or progenitor hormone.
Trenbolone , for example, is a derivative of the parent hormone Nandrolone. Each of these hormones share close properties with their parent hormones by virtue of the fact that they are derived from them, but in some rare occasions the derivative hormone is very much capable of exhibiting completely different properties that might seem to go against the logic in regards to the effects of steroids being shared or passed down from the progenitor hormone to its derivative.
Anadrol Oxymetholone is one such example, which is a derivative of DHT. Derivatives of DHT should normally exhibit no estrogenic effects on the body by virtue of the fact that they cannot convert aromatize into Estrogen. Although Anadrol too cannot aromatize, the current hypothesis is that it or its metabolites seems to act as an Estrogen itself in various tissues of the body .
This is a perfect example of how various anabolic steroids will exhibit different effects than others, and perhaps some will exhibit unpredictable effects in comparison to others. Desirable positive effects of steroids 2. Undesirable negative effects of steroids. What enables an anabolic steroid to exhibit positive or negative desirable or undesirable effects is very much limited to individual the individual, which makes the effects of steroids very relative to the individual.
For example, while many might regard the hair growth effect of steroids to be undesirable, there are in fact many individuals who seek the use of anabolic steroids for this effect, which is desirable, and therefore a positive effect.
In some cases, generalizations must be made even though in the abstract, such an issue is a grey issue rather than black and white. Another example of mixed opinions on an effect of steroids that might be desirable among some and undesirable among others is the fact that anabolic steroids for the most part tend to cause an increase in libido and sexual function .
However, because the increase in libido and sexual function is one of the effects of steroids that is desired by the majority of the population, such an effect is then considered to be a desirable effect even though, as previously mentioned, there exists a small percentage of the population that might regard the libido increases as an undesirable and therefore negative effect of steroids.
Everything else, and all other effects of steroids that an individual will experience during the course of an anabolic steroid cycle, whether desirable or undesirable, is secondary to this. Very rarely are anabolic steroids utilized without these two desirable effects as the primary goals in mind. In some cases, the off-label use of anabolic steroids might fall into a category of a desirable positive effect that an individual might be looking to use them for.
It is only within medicine that the applications of anabolic steroids are utilized without the two aforementioned desirable effects in mind. Various uses within medicine will be periodically mentioned and covered here as the effects are described.
It has been previously mentioned in the introduction that anabolic steroids exhibit a vast array of effects on the subsystems of the human body due to their nature as hormones, and many of these effects are the desired effects of steroids on the human body where the medical establishment is concerned.
For the purpose of physique and performance enhancement , which is what this article is most centered on, it is a slightly different story. However, the process by which anabolic steroids exactly and precisely influence muscle mass in all aspects and mechanisms is still not completely understood. It is presently understood that the primary means of action in terms of protein synthesis increase in muscle tissue is by way of the anabolic steroid binding to the cellcular androgen receptor, activating it, and essentially transmitting a message to the muscle cell to begin increases in protein synthesis.
This, however, cannot occur without proper physical stimulation beforehand through resistance training exercise , and hence why the common myth that anabolic steroids will make an individual big and muscular without any proper training or nutrition is simply not true. This creates a synergistic effect between the anabolic steroid and the other auxiliary hormones involved and interconnected in muscle growth.
Evidence of this can be seen in various anabolic steroids that in fact do not exhibit very significant binding strength to the androgen receptor, such as Dianabol Methandrostenolone where its effects lie in non-receptor mediated effects as evidenced by a particular study utilizing high doses of the compound that demonstrated a high level of nitrogen retention in the muscles promoted by Dianabol .
Anadrol Oxymetholone is another such anabolic steroid that exhibits poor androgen receptor binding strength but is known to be a very strong anabolic agent . In contrast, we can see how the effects of steroids differ between different steroids when we see how Testosterone itself in various studies has been found to exhibit no increases in tissue amino acid transport but indeed increases protein synthesis .
Increases in collagen synthesis and bone mineral content: All anabolic steroids to one degree or another exhibit the ability to increase bone strength through stimulation of increased collagen synthesis, an increase in bone mineral storage content, increases in new bone construction, and the inhibition of the resorption of bone bone breakdown . Collagen is the protein-based construction material that composes the key connective tissues throughout the body the joints, ligaments, tendons, cartilage, and bones themselves.
This tissue is what holds the different components of the body together, and there even exists collagen intertwined throughout muscle tissue itself the connective tissue between bundles of muscle fibers which holds the bundles together to form the muscle belly.
Even at relatively low HRT Hormone Replacement Therapy and TRT Testosterone Replacement Therapy doses of anabolic steroids, the effects of steroids on bone and connective tissue strength are quite profound and well-documented. It is the major reason as to why anabolic steroids are utilized in medicine for the purpose of osteoporosis treatment, and for the accelerated healing of bone fractures and bone frailty problems .
Such an increase from such a small and infrequent administration of Testosterone should provide a strong indication of the very beneficial effects of steroids on individuals with bone frailty associated with aging or for any other reason, especially the healing of bone injuries such as fractures.
It is already very well known that a deficiency in endogenous androgen levels for any reason, such as aging andropause , and hypogonadism, exhibit reduction in overall body height due to the natural deterioration of bone with age, as well as many other shortcomings in physical ability . This natural deterioration of bone with age results in a decreased body height, which is ultimately the result of decreased endogenous Testosterone production with age once again, properly termed andropause.
This is very evident especially even in females, whom naturally possess a significantly lower androgen level accompanied with a high Estrogen level than males 0. As a result, females exhibit a naturally shorter bodily height, far less muscle tissue than males, and are far more prone to age-related bone frailty osteoporosis in comparison to men.
For the athlete, these immense bone strengthening effects of steroids are very useful and very profound, where their use in sports that involve heavy contact and excess stress on the skeletal system would be assisted in a very positive and desirable way with the use of anabolic steroids. Technically belonging under the category of increased protein synthesis, the enhanced nutrient partitioning effects of anabolic steroids deserve their own descriptive portion.
The truth is that although many anabolic steroids do exhibit activity with the androgen receptor on adipose tissue fat tissue , it is not through this pathway that any significant fat loss occurs, which would be considered a direct effect on fat loss.
The fat loss resultant from the androgen receptor activity in fat cells is not very significant. However, it is in fact through indirect effects on fat loss by which the fat loss during an anabolic steroid cycle occurs. It is through the muscle growth and protein synthesis signaling effects on muscle tissue mentioned earlier that this very strong nutrient partitioning effect occurs.
With more muscle cells activated to engage in protein synthesis, the percentage of consumed calories to be utilized for this purpose now increases drastically. It is very obvious what this means for muscle growth: But what does this mean for fat loss?
In a direct sense, the enhanced nutrient partitioning does not metabolize fat directly, but with now more consumed nutrients being shuttled towards muscle growth and less towards fat storage, this opens a wider window and opportunity for the body to utilize fat storage for energy while fewer nutrients are being stored as fat. This increased nutrient partitioning is the number one key reason as to why anabolic steroids are utilized in farm cattle, so as to increase the feed efficiency and output of lean meats as opposed to fatty meats.
More meat for consumer consumption means more of the population can be effectively fed for a lower cost of production. Trenbolone is the primary anabolic steroid utilized to improve feed efficiency and fat-free mass addition in cattle, where it has been proven in studies to exceptionally reduce the concentration of fat deposits and drastically increase protein content in the form of lean muscle tissue in farm animals .
Increased hemoglobin red blood cell count: This could possibly be considered both a desirable positive as well as an undesirable negative effect of steroids. Hemoglobin is the protein contained in the center of each red blood cell, which is where oxygen becomes attached to when red blood cells travel to the lungs to pick up oxygen. The red blood cell then travels to various tissues and cells throughout the body to deliver the attached oxygen before returning to the lungs to allow more oxygen to attach to the hemoglobin protein.
Therefore, a rise in hemoglobin levels will always correlate with a rise in red blood cell count. Anabolic steroids stimulate cells in the kidneys to begin or increase the manufacture and secretion of a hormone known as Erythropoietin EPO. This process is known as Erythropoiesis. EPO then travels to the bone marrow in order to signal the production of new red blood cells. Within medicine, anabolic steroids are utilized for the treatment of anemia, which is a condition whereby an individual manufactures insufficient red blood cells for many different reasons , or expresses a low red blood cell count for various other reasons.
The effects of steroids on the hematological system in this regard are extremely beneficial for anemic patients. Anadrol Oxymetholone is one such anabolic steroid that has been specifically utilized almost exclusively for the treatment of severe anemic patients, as its efficiency at such a function has been proven to be exceptional even in anemic patients that have exhibited bone marrow failure .
All anabolic steroids exhibit what is known as an anti-catabolic effect on muscle tissues by way of acting as an anti-glucocorticoid. Glucocorticoids are steroid hormones known as corticosteroids, which act as stress hormones in the body and serve to do the exact opposite of anabolic steroids to muscle tissue: Anabolic steroids have demonstrated to be very effective suppressants of corticosteroids glucocorticoids in the body .
Corticosteroids engage in the breakdown of muscle tissue catabolism into amino acids as a stress response when the human body senses impending starvation or danger, and requires an immediate supply of nutrients in the bloodstream.
Glucocorticoids not only act to break muscle tissue down into amino acids, but also serve to cause a breakdown of carbohydrates from both the liver and muscle tissue for release as blood glucose, as once again, a stress response. While some moments might initiate a high level of glucocorticoid activity in this sense, other moments will normally express a lower and slower level of activity. Nevertheless, corticosteroids are constantly breaking down muscle tissue at a constant rate, though normal physiological functions should dictate a slow but steady rate.
It will not only increase the anabolic effects of steroids, but at the same time increase the suppressive effect of the catabolic effect of corticosteroids glucocorticoids by way of androgens causing glucocorticoids to be removed from their respective glucocorticoid receptors in muscle cells as demonstrated by studies . It has also been discovered through studies that androgens, such as Testosterone, will interfere with the DNA transcription process caused by glucocorticoid effects on the glucocorticoid receptors in muscle cells .
The majority of the undesirable and negative effects of steroids are, for the most part, very superficial cosmetic effects such as acne, potential hair loss, or gynecomastia. There exist several internal negative effects of steroids, but these are just as temporary while on a cycle as the undesirable cosmetic effects are. This article will cover the most questioned, and for the lack of a better term, the most popular of the negative effects of steroids among individuals.
It is important to understand the dynamics by which the negative effects of steroids work, and it is highly encouraged that individuals read the steroids side effects article for an all-encompassing in-depth coverage of all of the side effects of anabolic steroids and how and why they occur. This is not an all-inclusive list of the side effects of steroids, and it is very important for all readers to understand this.
The five primary negative effects of steroids are acne, gynecomastia, male pattern baldness MPB , hepatotoxicity liver toxicity. Perhaps the most superficial effect resultant of anabolic steroids, it tends to also be the most concerning among individuals looking to use anabolic steroids. This is likely because although one might desire a muscular physique, it might be embarrassing to unveil a physique that could potentially be covered in unsightly acne.
Anabolic steroids but more specifically their highly androgenic metabolites, such as Dihydrotestosterone affect androgen receptors located underneath the skin and the scalp, and through this they signal the sebaceous glands to begin or increase the secretion of sebum, which are the naturally occurring skin oils. The effects of steroids here in this particular area are also known for increasing the size of these glands .
Excessive sebaceous gland stimulation can result in follicles and pores becoming overloaded with sebum, dead skin, and dirt which results in acne.
This is not regarded as a life-threatening side effect and ranges in severity between individuals so much so that some may not experience acne at all, others may experience minor acne , and some will experience severe breakouts. The rate at which this affects individuals varies, and there is no general description as to how much or how little of an acne breakout an individual might experience on an anabolic steroid cycle. This is, without a doubt, the second most concerning effect that certain anabolic steroids can have upon a person.
Gynecomastia is the development of breast tissue on the male chest area. It is the result of rising Estrogen levels as a result of aromatization conversion of aromatizable androgens into Estrogen by the aromatase enzyme, which is the enzyme responsible for this conversion.
Estrogen is the primary culprit here in the development of breast tissue where it binds to receptors in breast tissue and initiates the growth processes of ductal epithelial hyperplasia, ductal elongation, and fibroblast proliferation . Gynecomastia can be prevented with the use of Estrogen blockers that block the effect of Estrogen at the breast tissue site, or through the use of aromatase inhibitors which serve to inhibit and disable the aromatase enzyme.