Page not availableThis paper summarizes the current knowledge concerning the biosynthesis of neurosteroids in the human brain, the enzymes mediating these reactions, their localization, and the putative effects of neurosteroids. The presence of the steroidogenic enzymes cytochrome P SCCaromatase, 5alpha-reductase, 3alpha-hydroxysteroid dehydrogenase, and 17beta-hydroxysteroid dehydrogenase in the human brain has now been firmly established by molecular biological and biochemical studies. Their presence in the cerebral cortex and in the subcortical white matter indicates that various cell types, neurosteroid metabolism in the human brain neurons or glial cells, are involved in the biosynthesis of neuroactive steroids in the brain. The following functions are attributed to specific neurosteroids: We still do not steroids first cycle results whether and how the steroidogenic enzymes are involved in the pathophysiology of the nervous system.
Neurosteroid metabolism in the human brain
Neurosteroid metabolism in the human brain. Abstract This review summarizes the current knowledge of the biosynthesis of neurosteroids in the human brain, the enzymes mediating these reactions, their localization and the putative effects of neurosteroids.
Cited By Sort by: Showing of 87 extracted citations. Pharmacological Potential and Pitfalls. Insight into the mechanism of action of neuroactive steroids. Confounding of the association between statins and Parkinson disease: Sex differences in the effect of finasteride on acute ethanol withdrawal severity in mice: University of Groningen PET imaging of brain sex steroid hormone receptors and the role of estrogen in depression Khayum, Mohamed Abdul Comparative aspects of neurosteroidogenesis: From fish to mammals.
Characterization of the 5alpha-reductase-3alpha-hydroxysteroid dehydrogenase complex in the human brain. Expression of the 17beta-hydroxysteroid dehydrogenase type 5 mRNA in the human brain. Association between changes in adrenal secretion and cerebral morphometric correlates in normal aging and senile dementia. Dehydroepiandrosterone DHEA supplementation for cognition and well-being.
Expression of 5a-reductase and 3ahydroxysteroid oxidoreductase in the hippocampus of patients with chronic temporal lobe epilepsy. Characterization of 17beta-hydroxysteroid dehydrogenase activity in brain tissue: Characterization of aromatase cytochrome P activity in the human temporal lobe. Similar Papers Loading similar papers…. Slides referencing similar topics.