Issues With Using Tamoxifen For BodybuildingPage 1 of 2 1 2 Last Jump to page: Results 1 to 10 of Nolvadex Tamoxifen Citrate use with Anabolic Steroids. Nolvadex, or Tamoxifen Citrate is a prescription drug that is used to treat breast cancer in both men and women. It can also be used as a preventive measure for tamoxifen whilst on steroids tamxoifen likely to develop breast cancer due to age, genetics, prices of anabolic steroids other high risk factors.
Tamoxifen(Nolvadex) for cycle
Page 1 of 2 1 2 Last Jump to page: Results 1 to 10 of Nolvadex Tamoxifen Citrate use with Anabolic Steroids. Nolvadex, or Tamoxifen Citrate is a prescription drug that is used to treat breast cancer in both men and women. It can also be used as a preventive measure for women more likely to develop breast cancer due to age, genetics, or other high risk factors.
Tamoxifen Nolva is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. Tamoxifen is the usual endocrine anti-estrogen therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting.
Some breast cancer cells can require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Because of this competitive antagonism, tamoxifen acts like a key broken off in the lock that prevents any other key from being inserted, preventing estrogen from binding to its receptor.
As a result, breast cancer cell growth is blocked. Tamoxifen was discovered by pharmaceutical company Imperial Chemical Industries now AstraZeneca and is sold under the trade names Nolvadex, Istubal, and Valodex. However, the drug, even before its patent expiration, was and still is widely referred to by its generic name "tamoxifen. While running aromatising compounds, such as testosterone, aromatase in the male body will convert it to form estradiol.
Too much estradiol estrogen in the male body can lead to several problems. The biggest problem being development of female breast tissue gynocomastia in men. Without controlling this issue, things can worsen, often leading to surgery as the only way to reverse this condition. High estrogen also contributes to things like water retention and bloat leading to loss in definition and smoothing out your physical condition. Higher estrogen levels also contribute to fat gain.
This is a big factor in why women typically have a higher bodyfat percentage than men. The benefits of Nolvadex during an anabolic steroid cycle: Nolvadex does not lower your estrogen level, but works to keep estrogen from binding to receptors in the body. With that said, many bodybuilders will use Nolvadex as a part of their steroid cycles. Since estrogen is necessary to build muscle, Nolvadex can be used on cycle to maximize gains without lowering estrogen and hindering muscle gain. The effects are especially apparent with those that have very low body fat, as Nolva can significantly increase hardness and lower water retention on cycle, leading to a much more dry and shredded physique.
Estrogen is essential for a properly functioning immune system and lipid profile. HCG, has a structure similar to that of luteinizing hormone LH , a pituitary gland hormone that controls testosterone synthesis in the Leydig cells of the testes.
The problem is, HCG stimulates estrogen synthesis as well as testosterone. So, bodybuilders often combine HCG with Nolvadex to prevent those estrogen side effects. So, when bodybuilders experience the symptoms of gynecomastia while they are on steroid cycle, they can rely on Nolvadex to immediately counter the problem.
However, a drawback of this drug is that it exhibits only short-term effects, which means that once Nolvadex intake is discontinued, the same problems can possibly rebound sooner than later.
To prevent this rebound, Nolvadex is generally use in conjunction with aromatase inhibitor. Nolvadex can deal with the problem right away while an aromatase inhibitor like Arimidex can work for the long-term results as it reduces the production of estrogen. Nolvadex benefits for post cycle therapy PCT: For reference and comparison, it would take roughly mg of Clomid each day to achieve the same level of result.
Nolvadex is also safer to use long term versus some of the other alternative ancillaries commonly used post cycle. Nolva has a much lower toxicity, and is just simply better suited for long term use without further having a negative impact on overall health, and even provides some nice health benefits. The downside and negatives of Nolvadex: Nausea, vomiting, and hot flashes are the most common. This happens when the adrenal glands are over stimulated to produce more dehydroepiandrosterone DHEA.
DHEA converts to estrogen. This isn't due, as previously thought, to its reducing estrogen levels which it doesn't , but rather to its ability to possibly reduce IGF Insulin-like-Growth-Factor levels, which are important for muscle growth. The myth of using Nolva with Nor Nandrolones: There is a lot of conflicting information out there, and one of the biggest things being spread around is to not use Nolvadex during a cycle with nandrolones such as Tren or Deca, and not in PCT.
The argument is that Nolva will up-regulate progesterone receptor activity, and since Nandrolones can increase progesterone levels, the combination leads to possible gyno problems. However, this is very far from the actual truth. In certain tissues, such as the endometrium uterus , upregulation of the PgR would be expected, since the endometrium is very sensitive to estrogen. This is where there is confusion that leads to the myth. In other tissues, such as the breast, Tamoxifen is an antagonist and blocks the estrogen receptor.
The progesterone receptor is synthesized in direct response to estrogen. When the estrogen receptor is blocked, the progesterone receptor will also down regulate. This is exactly the mechanism of action that happens in cancer patients, so we can expect the same result. There are no studies stating Tamoxifen up regulates the progesterone receptor in breast tissue, so its pure "bro-science" and speculation.
As with most things on the Internet, if you spread false information around to enough people it eventually gets accepted as the truth. It is important to also note that Tamoxifen does nothing to combat prolactin. To control prolactin, caber or Prami is taken. Want to know about research nolva? This is a very nice writeup with quality information Everyone needs to take the time to read and understand this Great article Wolf, You just answered my questions about gyno and Tamoxifen Citrate on my cycle.
Furthermore varying the compounds; Since we know both stimulate LH, what most don't know is that the act is different. Clomid boosts the amplitude of LH serum, but has no effect on the frequency. Nolvadex is the complete opposite in that area, where it boosts the actual frequency of LH and has no effect on its amplitude.
You're probably assuming they're identical and overpowering Nolva is also mixed, however There is a reason that Clomid is not recommended for gynecomastia reversal, but Nolva is. Can you recover with just Nolvadex, or just Clomid? Well, anything is possible. But why would you take that risk if the combination gives you a much better chance? To save a few bucks and risk your health? Clomid when coupled with Nolvadex is clearly the safer choice over using either compound individually.
Nolva boosts the effects of Clomid because it put Clomid into "competition" mode where they both fight for a receptors to bind to. This entire scenario is not as effective with only ONE drug. That's why we are here brother wolfie. Last edited by AnalogMan; at You have to make the mind run the body. Never let the body tell the mind what to do. The body will always give up.
It is always tired in the morning, noon and night. But the body is never tired if the mind is not tired. Really informative write up for sure. Just as everyone said, great article. Lots of good info to read. So what do you think the ideal dose is on cycle? Should one wait until they start to see possible gyno symptoms or should it be started when the cycle starts?