The very first compound isolated in pure form from the plant was cannabinol [ Wood, . The most researched compounds of the plant are dTHC and CBD and. at two compounds, CBD vs THC, and compare them on a number of different levels. Both may have benefits, but they differ despite having many similarities. With a rising demand for natural medicines, cannabis compounds, like CBD and THC share many similarities, but they also have distinct.
& Very CBD Compounds THC: Different
Structurally, however, there is one important difference. It is this seemingly small difference in molecular structure that gives the two compounds entirely different pharmacological properties. As with many of the cannabinoids, THC and CBD have low solubility in water, but good solubility in most organic solvents, particularly lipids and alcohols. Both THC and CBD are present in cannabis in a mixture of acidic forms, which are readily de-carboxylated and chemically altered upon heating, important when you consider that smoking cannabis is the most common form of consumption.
THC is also well known for its ability to bind to glass and plastic. Therefore, THC preparations are typically stored in basic or organic solvents in amber silicate glassware to avoid loss, especially during analytical testing procedures. THC is a potent partial agonist of CB1. It is this stimulation which leads to the major psychotropic effects of cannabis consumption.
CB1 is a G protein-coupled cannabinoid receptor located primarily in the central and peripheral nervous system with a particularly high abundance in the brain.
As part of the endocannabinoid system it is activated by the endogenous neurotransmitters, anandamide and 2-arachidonoylglycerol, as well as other naturally occurring compounds including the phytocannabinoids found in cannabis. As a potent partial agonist of CB1, THC stimulates the CB1 receptor leading to the psychotropic effects experienced when consuming cannabis.
CBD on the other hand, is classified as a negative allosteric modulator of CB1, meaning it effectively alters the shape of the CB1 receptor. Through its interactions with the CB1 receptor, CBD is thought to modulate the psychotropic effects of THC by inhibiting its ability to bind to and stimulate the receptor. CBD is able to reduce some of the negative effects of THC by decreasing anxiety, paranoia and the short-term memory impairment often experienced when consuming cannabis.
Evidence suggests that a CBD-rich product with little THC can in fact convey therapeutic benefits without having a euphoric or dysphoric effect. In broad terms, this reflects the consensus of the traditional pharmaceutical industry that a drug with a single active ingredient is easier to develop, test, produce, prescribe and regulate.
As evidence for the beneficial effects of combining cannabinoids in medicine increases this may change. Particularly with the growth in popularity of the concept of whole plant medicine.
Speaking of CBD and THC, it's important to know the difference between these two distinct compounds that interact with the body in very different ways. THC directly binds to CB1 receptors in the body, which are mainly found in the brain and nervous system. Once you know this, it's no big surprise to learn that this CB1 receptor activation is responsible for the "high" from smoking cannabis and that CBD does not directly bind with that receptor. Instead, CBD interacts with other receptors and pathways in the body that explain many of its specific health benefits.
CBD and THC have been described as "sister molecules" and one of the most interesting aspects of cannabinoid science is the " entourage effect, " which says that cannabinoids are more effective together than they are alone in isolated preparations.
This is part of the reason why when you're looking for cannabis products, experts recommend full-spectrum products which include some of the other cannabinoids and terpenes of the plant and to steer clear of isolates, which only contain the single compound and are generally less effective and more difficult to dose.
CBD and THC get a lot of the fame, but there are actually a bunch of cannabinoids worth learning about. Cannabinol CBN , which was actually the first cannabinoid to be discovered, is often used specifically for sleep. Other cannabinoids include cannabigerol CBG , cannabichromene CBC , and tetrahydrocannabivarin THCV , which are all of interest to doctors and researchers for their specific health benefits.
Unfortunately, many of these cannabinoids have barely been studied. Cannabinoids have a wide range of health benefits, ranging from THC's pain-relieving qualities to CBD's anti-anxiety properties. Other areas of research include cannabinoid therapy for PTSD, seizures, depression and anxiety , cancer and cancer-treatment-related symptoms , pain, and addiction especially to opioids. Most of these areas of research are in the preliminary stages, although a CBD-derived pharmaceutical drug was just approved by the FDA for seizure disorders, and THC-based drugs have been available for pain and a few other conditions for quite some time.
As research continues, we'll better understand cannabis and the health benefits of specific cannabinoids. Unfortunately, though, the way current laws are set up, it's extremely difficult to get approval to study cannabis and even more difficult and time-intensive to get high-quality plant materials to use in research. Hopefully, as more patients ask their doctors about cannabis-based therapies and more states approve recreational and medicinal marijuana, that will change.
The difference between CBD oil and hemp oil not to be confused with hemp seed oil, which is made from the sterilized seeds of the plant and doesn't have significant cannabinoid content can also be a source of confusion. Essentially, hemp oil is an extract from the whole plant and will contain a variety of cannabinoids—including CBD.
CBD is available on its own in a form commonly referred to as a CBD isolate , but hemp and cannabis experts don't typically recommend CBD isolates, as you miss out on the beneficial entourage effect.
So there you have it! You can now show off your newfound cannabinoid knowledge to all of your friends and help dispel common myths and misconceptions about the plant.
Despite the modern-day stigma, cannabis and cannabinoids have been used for centuries as plant medicines and have a lot of potential to help people all over the world, which is just one more reason to stay up-to-date on the science and policy surrounding this pretty miraculous plant!
Have more questions about cannabinoids? Here's what doctors have to say about CBD oil. Food has the power to create a happier and healthier world. Celebrity Nutritionist Kelly LeVeque will show you how.
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CBD (Cannabidiol) is a compound found in the Cannabis plant. It can be used in several different ways including vaping, tinctures, capsules, and edibles. Because of this, CBD became a very popular option for those. THC! CBD! Terpenoids! Cannabis Science Is Getting Hairy For example, THC feels different when combined it with cannabidiol, or CBD, of hundreds of other compounds in the plant that scientists know about so far. So far, CBD is the most promising compound from both a marketing and . It's what makes us different to so many others in the media, at a time.