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Why CBD?

More and more renowned scientists worldwide publish their researches on the favorable impact of CBD on the human body. Not only does this natural compound deal with physical symptoms, but also it helps with emotional disorders. Distinctly positive results with no side effects make CBD products nothing but a phenomenal success.

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Range of Products

We have created a range of products so you can pick the most convenient ones depending on your needs and likes.

CBD Capsules Morning/Day/Night:

CBD Capsules

These capsules increase the energy level as you fight stress and sleep disorder. Only 1-2 capsules every day with your supplements will help you address fatigue and anxiety and improve your overall state of health.

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CBD Tincture

CBD Tincture

No more muscle tension, joints inflammation and backache with this easy-to-use dropper. Combined with coconut oil, CBD Tincture purifies the body and relieves pain. And the bottle is of such a convenient size that you can always take it with you.

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Pure CBD Freeze

Pure CBD Freeze

Even the most excruciating pain can be dealt with the help of this effective natural CBD-freeze. Once applied on the skin, this product will localize the pain without ever getting into the bloodstream.

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Pure CBD Lotion

This lotion offers you multiple advantages. First, it moisturizes the skin to make elastic. And second, it takes care of the inflammation and pain. Coconut oil and Shia butter is extremely beneficial for the health and beauty of your skin.

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Epidemiological Reports and Surveys

are antioxidants and neuroprotective (−)Δ9-tetrahydrocannabinol Cannabidiol

Niss
26.06.2018

Content:

  • are antioxidants and neuroprotective (−)Δ9-tetrahydrocannabinol Cannabidiol
  • Is Cannabidiol the Next Clinical Antioxidant?
  • Mini Review ARTICLE
  • Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants Antioxidants such as α-tocopherol (5, 6) are effective. Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective several synthetic cannabinoids all were demonstrated to be antioxidants by. Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants. A. J. Hampson, M. Grimaldi, J. Axelrod, and D. Wink. PNAS July 7, 95 (14).

    are antioxidants and neuroprotective (−)Δ9-tetrahydrocannabinol Cannabidiol

    Biochemical and biophysical research communications 2 , , European Journal of Neuroscience 11 8 , , European Journal of Neuroscience 13 8 , , Journal of Biological Chemistry 47 , , European journal of pharmacology 3 , , Current pharmaceutical design 17 3 , , Journal of Biological Chemistry 11 , , European Journal of Neuroscience 12 10 , , CBD has also been shown to have low affinity for both cannabinoid receptors Petitet et al.

    Interestingly, CBD antagonizes CP 55, at a much lower concentration than it binds to the cannabinoid receptors, suggesting it may act at a prejunctional site which is not the cannabinoid receptors Pertwee et al.

    CBD acts as an inverse agonist at the CB 2 receptors, which may explain some of its anti-inflammatory properties as inverse agonists at CB 2 receptors are able to inhibit the migration of immune cells Lunn et al. Finally, CBD interacts with various neurotransmitter systems including glutamate receptors [i.

    The in vivo therapeutic potential of CBD in AD has not been widely documented, however, there are a number of studies that have reported the effect of CBD in pharmacological models of AD e.

    These studies have described anti-inflammatory and neuroprotective effects of CBD. GFAP is the best known marker of activated astrocytes and thought to be one of the main features of reactive gliosis Esposito et al. NO is a free radical and important in neuroinflammatory and neurodegenerative conditions, which include accelerating protein nitration and increasing tau hyperphosphorylation Esposito et al.

    Finally, the ability of CBD to attenuate reactive gliosis may result from CBD's ability to act as an inverse agonist at the cannabinoid receptor 2 CB 2 , which is thought to be involved in reactive gliosis Walter and Stella, ; Thomas et al. The anti-inflammatory and neuroprotective effects of CBD were further investigated in a rat model of AD-related neuroinflammation.

    CBD's ability to reduce reactive gliosis is further emphasized by the inhibition of SB. Finally, the study found that CBD was able to restore CA1 pyramidal neurons to a similar integrity to that of the control rats. CBD also down-regulated gliosis and repaired neurogenesis in the dentate gyrus Esposito et al. Three-month old mice were intraventricularly injected with 2. Although pharmacological models of AD are useful in producing AD-like symptoms, it is necessary to investigate the effects of CBD in transgenic mouse models as they result from gene mutations, which are seen in familial AD e.

    Initially, two studies were conducted in our laboratories to elucidate the remedial and preventative potential of chronic CBD treatment in AD transgenic mice. CBD treatment was able to reverse cognitive deficits in object recognition memory and social recognition memory without influencing anxiety parameters Cheng et al.

    Furthermore, cortical lipid oxidation levels were not altered by CBD treatment. However, the study did report a complex interaction between CBD treatment, AD genotype and cholesterol and phytosterol levels, suggesting they may be involved in the mechanisms behind the beneficial effects of CBD.

    There was also a subtle impact of CBD on inflammatory markers of the brain Cheng et al. Further research will be necessary to elucidate the potential mechanisms further, thereby also considering other treatment designs i. Importantly, there is controversy about what the ratios of CBD: The first study conducted by Casarejos et al.

    This mouse model was foremost a model of frontotemporal dementia, parkinsonism and lower motor neuron disease. The second study conducted by Aso et al. This study found that all treatments improved memory deficits in the two-object recognition task but only the CBD-THC combination prevented the learning deficit seen in the active avoidance task.

    Finally, reduced astrogliosis, microgliosis and inflammatory related molecules were more pronounced after treatment with the CBD-THC combination than either phytocannabinoid individually Aso et al. This suggests that when CBD and THC are combined there may be either a summative effect or an interaction effect between the compounds, which potentiates their therapeutic-like effects Aso et al.

    In this context, it should be mentioned, that although all treatments had cognition-improving characteristics in the object recognition task, THC alone had a detrimental effect on cognition in control mice, highlighting the need to be cautious when considering THC as a therapeutic. In a very recent follow-up study, Aso et al. Compared to the non-aged controls, vehicle-treated aged mice demonstrated impaired cognition in the two-object recognition task.

    AD is a debilitating neurodegenerative disease that is becoming increasingly common in today's society. Unfortunately, there is still no effective treatment that stops or reverses the disease progression.

    However, further dose-dependent investigations into transgenic mouse models of AD are necessary to understand the full potential and the long-term effects of CBD.

    Importantly, many of the discussed studies were conducted in mice aged between 3 and 6 months, which is quite young considering AD diagnosis is usually relatively late in the disease progression. Furthermore, it is necessary to investigate the effects of CBD in tauopathy mouse models specific to AD and in female mouse models as all studies reviewed were conducted in male mice only.

    Nevertheless, the studies discussed here provide promising preliminary data and the translation of this preclinical work into the clinical setting could be realized relatively quickly: CBD is readily available, appears to only have limited side effects Bergamaschi et al. TK and GW were both involved in the conceptualization, reference search, and writing of this mini review. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

    Cooper Limited Research Foundation. We thank Jerry Tanda for critical comments on the manuscript. Cannabinoids in late-onset Alzheimer's disease.

    Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes Dose-related differences in the regional pattern of cannabinoid receptor adaptation and in vivo tolerance development to delta9-tetrahydrocannabinol Endocannabinoid Signaling Regulates Sleep Stability Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol Enhanced discriminative stimulus effects of 9-THC in the presence of cannabidiol and 8-OH-DPAT in rhesus monkeys Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons of Metestrous Mice: Importance for development and in pediatric disease The Endocannabinoid System as an Emerging Target of Pharmacotherapy The Endocannabinoid System, Cannabinoids, and Pain The endocannabinoid system in normal and pathological brain ageing The endogenous cannabinoid system and its role in nociceptive behavior The orphan receptor GPR55 is a novel cannabinoid receptor.

    An Acute Slice Electrophysiological Study Presence of functional cannabinoid receptors in human endocrine pancreas The effects of delta9-tetrahydrocannabinol and cannabidiol on the metabolism of gonadal steroids in the rat. Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine Cannabidivarin CBDV suppresses pentylenetetrazole PTZ -induced increases in epilepsy-related gene expression Cannabidivarin is anticonvulsant in mouse and rat Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism Cannabinoids for pediatric epilepsy?

    Up in smoke or real science? A Scientific Review CBD-enriched medical cannabis for intractable pediatric epilepsy; The current Israeli experience Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients On the application of cannabis in paediatrics and epileptology Parent use of cannabis for intractable pediatric epilepsy: Everyday empiricism and the boundaries of scientific medicine Redistribution of CB1 Cannabinoid Receptors in the Acute and Chronic Phases of Pilocarpine-Induced Epilepsy Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy The case for assessing cannabidiol in epilepsy The case for medical marijuana in epilepsy The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy Understanding Cannabinoids and Epilepsy.

    Delta-9 tetrahydrocannabinol THC inhibits lytic replication of gamma oncogenic herpesviruses in vitro. Cannabinoids and Cystic Fibrosis: A Novel Approach to Etiology and Therapy.

    Clearing Away the Smoke Pharmacological actions and therapeutic uses of cannabis and cannabinoids Phytocannabinoids beyond the Cannabis plant — do they exist? Delta-9 tetrahydrocannabinol THC inhibits lytic replication of gamma oncogenic herpesviruses in vitro The effect of deltatetrahydrocannabinol on herpes simplex virus replication Cannabinoids as pharmacotherapies for neuropathic pain: Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.

    Short-term efficacy of CBD-enriched hemp oil in girls with dysautonomic syndrome after human papillomavirus vaccination.

    Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties Cannabinoids and the immune system CB2 cannabinoid receptors as an emerging target for demyelinating diseases: Endocannabinoids, feeding and suckling — from our perspective Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage The Endocannabinoid-CB Receptor System: Importance for development and in pediatric disease.

    Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol — studies in BV-2 microglia and encephalitogenic T cells Anti-Inflammatory Role of Cannabidiol and O in Cerulein-Induced Acute Pancreatitis in Mice Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: Clinical endocannabinoid deficiency CECD revisited: Cannabinoids inhibit neurodegeneration in models of multiple sclerosis CB2 cannabinoid receptors as an emerging target for demyelinating diseases: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression Cannabidiol for the Prevention of Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplantation: Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice Endocannabinoids in Liver Disease Exogenous hepatitis B virus envelope proteins induce endoplasmic reticulum stress: Extraction of cannabinoids from cannabis sativa L plant and its potential antimicrobial activity In vitro antibacterial activity of Cannabis sativa leaf extracts to some selective pathogenicbacterial strains.

    Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: Evidence from Cannabidiol Treatment The cannabinoid receptor agonist WIN facilitates the extinction of contextual fear memory and spatial memory in rats Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons. Implications for Neuropsychiatric Disorders Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances Cannabidiol as a potential treatment for psychosis Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia Cannabidiol, neuroprotection and neuropsychiatric disorders Cannabidiol reverses MKinduced disruption of prepulse inhibition in mice Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: Additional evidence Cannabinoids in bipolar affective disorder: Activation of CB2 receptors as a potential therapeutic target for migraine: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions Comprehensive Review of Medicinal Marijuana, Cannabinoids, and Therapeutic Implications in Medicine and Headache: Implications in Migraine The endocannabinoid system and migraine.

    Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis:

    Is Cannabidiol the Next Clinical Antioxidant?

    The neuroprotection observed with cannabidiol and THC was unaffected of the oxidation potentials of cannabinoids and the antioxidant BHT. the antioxidant capacity of THC and CBD, generating a useful (IP, in kcal mol− 1) and the O-H bond dissociation (BDE, in kcal .. of Alzheimer's disease pathology by cannabinoids: Neuroprotection Huestis, M.A. Pharmacokinetics and Metabolism of the Plant Cannabinoids, Δ9-Tetrahydrocannibinol. #CBD & #THC are Neuroprotective #Antioxidants cialispanettet.top Anandamide Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective .

    Mini Review ARTICLE



    Comments

    Potter

    The neuroprotection observed with cannabidiol and THC was unaffected of the oxidation potentials of cannabinoids and the antioxidant BHT.

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