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The citizens use of cannabis. Hickenlooper explained to the media: Sup- this industry will create jobs. Similar to Portland, state law where 16, , the Denver City Council adopted an ordinance for only medical marijuana is legal will likely be enforced, as retail marijuana establishments.
Initiative 71 legalized the recreational usage of marijuana, with laws similar to those State-level legalization of Colorado and Washington. Unlike Ini- tiative , Amendment 64 allows personal cultivation of Territorial-level legalization up to 6 plants. Both provide for commercial cultivation and sales, subject to regulation and taxes. In December , the resolved. US Virgin Islands passed a bill that decriminalized posses- The city of Portland, Maine legalized the possession of up sion of cannabis up to an ounce.
As with The act: State and Territories, the Federal government will not inter- vene as long as the reservations regulate strict control over Would reschedule marijuana from a Sched- marijuana.
Some domestic nations such as the Yakama Na- ule I to Schedule II drug to recognize it has ac- tion and the Oglala Sioux Tribal Council rejected the ap- cepted medical use, and would amend federal law proval to allow marijuana on their reservation.
The leg- islation would not legalize medical marijuana in all 50 states, rather it would respect the states 1. It was read twice and referred to the Com- The act has not yet been approved by the Congress. The intentions of the bill are to limit the application of Federal laws to the distribution and Respect State Marijuana Laws Act consumption of marijuana, and for other purposes.
Drug court to drug policy reformation. The conventional criminal court with the possibility of serving bill was approved by the House in September Should the of-  Jones, Nick A Celebration of Cannabis Cul- fender fail to comply with one or more of the requirements ture.
Septem- ber 14, Retrieved March 9, Puts a Ban on Hashish. Hemp — American History Revisited. Retrieved September 4, Drug Use and Abuse 4th ed. Drug Problems 26 2. Retrieved February 13, Bureau of Chemistry Plant Which Crazes Its Addicts. Whitebread and Richard J. A History of American Marihuana Prohibition. University of Virginia Law School. American and Canadian Plains, — The Life of William Randolph Hearst: Anslinger and the Federal Bureau of Narcotics, — University of Delaware Press.
The Borderlands of the Ameri- University of Nebraska Press. Re- trieved May 26, Retrieved May 15, Re-  Rowe, Thomas C. Federal narcotics laws and the trieved March 25, Encyclopedia of Law Enforcement: Retrieved war on drugs.
ISBN March 9, Commissioner of Narcotics and Will Oursler: The Murderers, the story of the narcotic  American Chemical Society: Dewey and Jason L. Retrieved March 25, Retrieved  Hayo M.
Randall Fortenbery and Michael Bennett: Is Industrial  Volz, Matt July 11, The Seattle Times Frank A. Retrieved April 20, Retrieved March  Pub. Governor's Drug Policy mission Illinois to the Illinois General Assembly. Retrieved March 20, Illinois Legislative Investigating Commission. Retrieved July 7, Archived from the original on September 28, Retrieved April 30, Retrieved Jan- uary 2, The New York Times. Retrieved July 28, trieved March 9, Retrieved May 26, Brief History of Social Problems: United States Department of State.
Retrieved cal thinking approach, Retrieved June 8, Retrieved May 26,  "http: Medical marijuana ruling puts spotlight on pend- ment of Justice, October 19, , http: San Francisco Bay Guardian. Retrieved April 24, Cultural and Historical Perspectives. ISBN  http: New York Daily Retrieved May 29, The Denver cember 24, Post. Retrieved September 20, Re-  Nick Allen December 31, Retrieved September 19, Retrieved February 27, Retrieved November 16, Retrieved February 26, American history re- visited: It implies an overwhelming in- ufacture, importation, possession, use and distribution of dictment of the behavior which we believe is not certain substances is regulated.
It was passed by the 91st appropriate. The actual and potential harm of use United States Congress as Title II of the Comprehensive of the drug is not great enough to justify intrusion Drug Abuse Prevention and Control Act of and signed by the criminal law into private behavior, a step into law by President Richard Nixon.
Single Convention on Narcotic Drugs. Congress has sometimes scheduled respects to liberalize, American drug policy. It elim- , which placed gamma hydroxybutyrate in Schedule I. States, and international treaties. The bill, as introduced by Senator Everett Dirksen, ran to 91 pages. While it was being drafted, the Uniform Controlled 1. Mitchell, was preparing a com- Substances. This re- ber 11, Once the stances EPCS Under certain circumstances, the The Controlled Substances Act consists of 2 subchapters.
In ad- ates lawful and unlawful manufacturing, distribution, and dition, 21 U. In any case, once these proceedings are complete, the temporary order is automatically vacated. Unlike ordinary scheduling pro- 1.
The ings to add, delete, or change the schedule of a drug or other cornerstone of this system is the registration of all those substance may be initiated by the DEA, the Department of authorized by the DEA to handle controlled substances. When a petition is received by the DEA, the agency begins its own investigation of the drug. The prohibitions of the the equality of treaties and Congressional acts. Covert the Supreme Court of the United States addressed Constitution were designed to apply to all branches of the National Gov- both these issues directly and clearly holding: This Court has reg- Constitution.
For example, in Geofroy v. It would not be con- which intimates that treaties and laws tended that it extends so far as to au- enacted pursuant to them do not have thorize what the Constitution forbids, to comply with the provisions of the or a change in the character of the Constitution.
It would treaties which concluded the Revo- be completely anomalous to say that a lutionary War, would remain in ef- treaty need not comply with the Con- fect. It would be manifestly con- stitution when such an agreement can trary to the objectives of those who be overridden by a statute that must created the Constitution, as well as conform to that instrument.
Congress and the President of the United a treaty obligation under the Convention States have the absolute sovereign right to withdraw from on Psychotropic Substances. However, the Secretary has obligations violate the United States Constitution. If the Secretary agrees with the Commis- sion's scheduling decision, he can recommend that the At- torney General initiate proceedings to reschedule the drug 1.
The temporary scheduling expires as scheme. The term does not include ing; however, control was required by the Convention on distilled spirits, wine, malt beverages, or tobacco, Psychotropic Substances.
It has been shown to be asso- ciated with an increase in seizures if taken alone. MDMA, it can produce neuroadaptations that can cause an increase in the potential for abuse of this 1. The drug or other substance has a high drug. The drug or other substance has no cur- the shrub Catha edulis khat. There is a lack of accepted safety for use of psychedelic drug that is widespread throughout the the drug or other substance under medical plant kingdom and endogenous to the human body.
The medical community orig- tion of a practitioner, except that in emergency situations, inally agreed upon placing it as a Schedule III sub- as prescribed by the Secretary by regulation after consulta- stance, but the government denied this suggestion, de- tion with the Attorney General, such drug may be dispensed spite two court rulings by the DEA's administrative upon oral prescription in accordance with section b law judge that placing MDMA in Schedule I was ille- of that Act 21 USC b.
With exceptions, an orig- gal. To provide relief, in , 21 C. The drug or other substances have a Dexmethylphenidate Focalin: The drug or other substance has a currently accepted obesity medical use in treatment in the United States. Substances Act than for Schedule II though no schedule has Prior to October , formulations containing hy- provisions to address circumstances where the closed sys- drocodone and over-the-counter NSAIDs such as Ac- tem is unavailable, nonfunctioning or otherwise inadequate.
Drugs in this schedule include: The drug or other substance has a potential for abuse Xyrem is in Schedule III but with a restricted distribu- less than the drugs or other substances in schedules I tion system. The drug or other substance has a currently accepted medical use in treatment in the 1. Abuse of the drug or other substance may Main article: Control measures are similar to Schedule III. The drug or other substance has a low within a six-month period.
A prescription for controlled potential for abuse relative to the drugs or substances in Schedules III, IV, and V issued by a practi- other substances in schedule IV tioner, may be communicated either orally, in writing, or 2. Abuse of the drug or other substance may Additionally, the law restricts an individual to the retail lead to limited physical dependence or psy- purchase of no more than three packages or 3. A violation of this statute con- stitutes a misdemeanor.
Retailers now commonly require No controlled substance in schedule V which is a drug PSE-containing products to be sold behind the pharmacy may be distributed or dispensed other than for a medical or service counter. Difenoxin with atropine Motofen has drugs. Without atropine, these drugs are in Schedule II. That bill was then super- seded by the Combat Methamphetamine Epidemic Act of , which was passed as an amendment to the Patriot 1.
Raich  The Act: Oakland Cannabis Buyers' Cooperative . Cato Handbook for Congress: It is an eclec- Archive copy at the Wayback Machine tic concept having only one uniform connotation: A Modern History vey on Drug Abuse. Their Derivatives  21 U. Federal Register Drug ica: Clinical Toxicology 46 9: Clinical Toxicology 35 6: Drug harms in the UK: A multicriteria decision doi: The Lancet, , Retrieved 30 October Retrieved 3 September The most notable cannabinoid is the phy- doi: The botany and CBD is another major constituent of the plant.
CB1 re- ceptors are absent in the medulla oblongata, the part of the brain stem responsible for respiratory and cardiovascular functions. Cannabinoid receptor type 2 Main article: While found only in the peripheral nervous system, a report does indicate that CB2 is ex- pressed by a subpopulation of microglia in the human cerebellum.
It is only mildly psychoactive. Cannabigerol Tetrahydrocannabinol Main article: CBG has been shown to promote apoptosis in cancer cells and inhibit tumor growth in mice. Recent evidence shows that the compound counteracts cognitive impairment associated with the use of cannabis. Cannabichromene activity on human breast carcinoma by inhibiting cancer cell growth. CBD has been shown to play a role in preventing the short-term memory loss as- Biosynthesis Cannabinoid production starts when an sociated with THC.
For the propyl homo- chosis. Trials indicated it was safe and well tolerated. Cannabis plants can exhibit wide variation in the quantity and type of cannabinoids they produce. Selective breeding has been used to position of the double bond in the alicyclic carbon ring. Under the dibenzopyran numbering system choactive chemicals like THC. Liquid chromatography LC techniques are also pounds.
There have to the aromatic ring. In the most common of cannabis over time, but their accuracy is impeded by the homologue, the pentyl chain is replaced with a propyl 3- illegal status of the plant in many countries.
Pharmacology Cannabinoids can be administered by smoking, vaporiz- ing, oral ingestion, transdermal patch, intravenous injec- Cannabinoids in other plants tion, sublingual absorption, or rectal suppository. Once in the body, most cannabinoids are metabolized in the liver, Phytocannabinoids are known to occur in several plant especially by cytochrome P mixed-function oxidases, species besides cannabis. Hydrocarbons and alcohols are often Most of the phytocannabinoids are nearly insoluble in wa- used as solvents.
Butane may be used, which evap- organic solvents. Due to molecular similarity and ease of synthetic conver- All of these are members of a family of signalling sion, CBD was originally believed to be a natural precursor lipids called N-acylethanolamines, which also includes to THC.
Arachidonoylethanolamine nal immobility, and mild antinociception in mice. It binds primarily to the CB1 receptor, and only weakly to the CB2 receptor. Anandamide is derived from N-Arachidonoyl dopamine arachidonic acid.
Activation of cannabinoid receptors temporar- for the vanilloid receptor subtype 1 TRPV1 , a member of ily reduces the amount of conventional neurotransmitter re- the vanilloid receptor family. Virodhamine cell depends on the nature of the conventional transmit- ter being controlled.
Al- is an increase in the excitability of the endocannabinoid- though it is a full agonist at CB2 and a partial agonist at releasing cell. On the converse, when release of the ex- CB1 , it behaves as a CB1 antagonist in vivo. In rats, virod- citatory neurotransmitter glutamate is reduced, the net ef- hamine was found to be present at comparable or slightly fect is a decrease in the excitability of the endocannabinoid- lower concentrations than anandamide in the brain, but 2- releasing cell.
Lysophosphatidylinositol LPI Recent evidence has They cannot travel unaided for long distances in the aqueous highlighted lysophosphatidylinositol as the endogenous lig- medium surrounding the cells from which they are released, and to novel endocannabinoid receptor GPR55, making it and therefore act locally on nearby target cells. Hence, al- a strong contender as the sixth endocannabinoid. Function Endocannabinoids serve as intercellular 'lipid messengers', 1.
Although in this intercellular signaling role they are similar to the well-known monoamine neurotransmitters, Historically, laboratory synthesis of cannabinoids were of- such as acetylcholine and dopamine, endocannabinoids dif- ten based on the structure of herbal cannabinoids, and a fer in numerous ways from them.
For instance, they are large number of analogs have been produced and tested, used in retrograde signaling between neurons. Further- especially in a group led by Roger Adams as early as more, endocannabinoids are lipophilic molecules that are and later in a group led by Raphael Mechoulam. Newer not very soluble in water. They are not stored in vesicles, compounds are no longer related to natural cannabinoids and exist as integral constituents of the membrane bilay- or are based on the structure of the endogenous cannabi- ers that make up cells.
They are believed to be synthe- noids. The mechanisms and enzymes underlying the biosynthesis Synthetic cannabinoids are particularly useful in exper- of endocannabinoids remain elusive and continue to be an iments to determine the relationship between the struc- area of active research. Endocannabinoids, on the other Medications containing natural or synthetic cannabinoids or hand, are described as retrograde transmitters because they cannabinoid analogs: Pharmacological Reviews 58 3: CB1 receptor inverse agonist once used as an anti- doi: It  Lambert, Didier M.
Journal of Medic- inal Chemistry 48 Other notable synthetic cannabinoids include: Journal of Natural Products 79 2: Retrieved 6 June A Cellular and Molecular Approach. Progress in Lipid Research 50 2: European Journal of Biochemistry 6: US Patent application number: Some physical and chemical fea- Bulletin on narcotics 32 2: Schizophrenia Research American Journal of Botany 91 6: British Journal of Pharmacol- ogy 7: Neurochemical Research 30 8: Behavioural Pharmacology 16 5—6: The Journal of Pharmacol-  http: Retrieved 6 October Journal of Medicinal Chemistry 43 Planta Medica 63 1: British Journal of Pharmacology 1: Journal of Chromatography A 2: Plant Physiology 4: The plant-derived yangonin is a novel CB1 recep- Pharmacological Research 66 2: Drug Metabolism Reviews 46 1: Pro-  Ashton CH February Br J Psychiatry 2: They are then slowly released back into other body Mayumi; Suhara, Yoshitomo; Takayama, Hiroaki; Waku, compartments, including the brain.
They are then slowly Keizo; Sugiura, Takayuki Journal nation half-life of THC is about 7 days, and complete elim- of Neurochemistry 85 6: Annual Review of Neu- Yu. Novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with  Grotenhermen, Franjo Life Sciences 65 6—7: Life Sciences 78 macology and Experimental Therapeutics 3: Journal of Medicinal Chem- istry 36 Update on Chemistry, new cannabinoid acids from Cannabis sativa L.
Med can Journal of Drug and Alcohol Abuse 0 0: Drug and Chemical Schatz, Anthony R. Oc- cal Pharmacology 50 1: Journal of Neuroscience 28 Science Rehnelt, J. In , the binding of several cannabinoids Journal of Natural Products 44 1: Cannabinoids bind reversibly and stereo-selectively to the cannabinoid receptors. Subtype se- lective cannabinoids have been developed which theoreti- cally may have advantages for treatment of certain diseases 1.
Cannabinoid receptor type 1 Cannabinoid receptor type 1 CB1 receptors are thought to be one of the most widely expressed G protein-coupled receptors in the brain. This is due to endocannabinoid- mediated depolarization-induced suppression of inhibition, a very common form of short-term plasticity in which the depolarization of a single neuron induces a reduction in GABA-mediated neurotransmission. Endocannabinoids released from the depolarized post-synaptic neuron bind to CB1 receptors in the pre-synaptic neuron and cause a re- CB1 and CB2 structures.
Cannabinoid receptors, located throughout the body, are They are also found in other parts of the body. For instance, part of the Endocannabinoid system which is involved in a in the liver, activation of the CB1 receptor is known to in- variety of physiological processes including appetite, pain- crease de novo lipogenesis. A study suggested that the endocannabinoids and their Cannabinoid receptors are of a class of cell membrane cannabinoid receptors play a major role during pre- and receptors under the G protein-coupled receptor superfam- postnatal development.
All of the endo- 1. Cannabinoid receptor type 2 There are currently two known subtypes of cannabinoid re- ceptors, termed CB1 and CB2. The CB2 hematopoietic cells. They also have a function in receptor is expressed mainly in the immune system and in keratinocytes.
They are also expressed on peripheral nerve hematopoietic cells. In the brain, they are mainly expressed and non-CB2 , which are expressed in endothelial cells and by microglial cells, where their role remains unclear.
This ef- through activation of GPR Sub- sequent studies showed that GPR55 does indeed respond to cannabinoid ligands. CB2 is expressed erated naturally inside the body endocannabinoids or in- in osteoblasts, osteocytes, and osteoclasts. CB2 agonists en- troduced into the body as cannabis or a related synthetic hance endocortical osteoblast number and activity while re- compound. PMID Several synthetic cannabinoids have been shown to bind to One of the described compounds, a classical TI THC-type cannabinoid, L,, in which the phenolic —4.
Certain tumors, especially gliomas, express CB2 receptors. PMID and smoking cessation see Rimonabant. CB1 provides neuroprotection after brain injury. Journal of Molecular Modeling 17 9: Prostaglandins Other Lipid Mediat. Addict Biol 13 2: J Am Coll Cardiol. PMID tive stress and cell death in murine models of doxorubicin- Free Radic Biol Med.
Drug  Gaoni Y, Mechoulam R International Union of Basic doi: Not to be confused with cannabinol or cannabinodiol. Retrieved 11 June It is a catastrophic form of intractable epilepsy that begins in infancy.
Epidiolex was granted fast- track status and is in late stage trials following positive 1. At room temperature, it is a col- receptors but acts as an indirect antagonist of their orless crystalline solid. FEBS Letters Nagaraja, Kodihalli Nanjappa, Synthesis of delta- are considered hemp, or considered marijuana. Tetrahydrocannabinol Isomerism, Abnormal cannabis. Non-psychoactive hemp also commonly-termed cannabidiol.
UK Cannabidiol, in an oral-mucosal spray formulation Soc. PMID tion product available for relief of severe spasticity due to Epilepsia Review 55 6: Retrieved 15 December Phytother Res  Angus, Chen 8 December Retrieved 14 December Retrieved 7 January PMID Free full text Iwasaki K, Fujiwara M March Naunyn-Schmiedeberg's Archives of Pharmacology 5: Drug Metabolism and Disposition 23 8: British Journal of Pharmacology 7: PMID ogy 2: Joca SR January Statement on a non- cannabidiol in mice: Retrieved 21 July Tetrahedron Letters 26 8: Journal of Experimental Botany 60 Not to be confused with cannabidiol or cannabinodiol.
Cannabinol CBN is a weak psychoactive cannabinoid found only in trace amounts in Cannabis sativa and  Fournier, G. CBN is then formed by de- doi: Journal of Medic- inal Chemistry 43 Cannabis drug and Hemp  David R. They can also be used as caged-bird feed, as they provide a moder-  Sigma-Aldrich Co. A Cannabis plant in the vegetative growth phase of its life requires more than 12—13 hours of light per day to stay veg- etative.
Flowering usually occurs when darkness equals at least 12 hours per day. In soil, the optimum pH for the plant is 6. In hydroponic growing, the nutrient solution is best at 5.
A nominal if not legal distinction is often made between industrial hemp, with concentrations of psy- and ointments have also been common preparations. In choactive compounds far too low to be useful for that traditional medicine of India in particular C. Male plants shed their pollen and die several weeks prior to seed ripening on the female plants. Although genetic factors dispose a plant to become male or female, environmental factors includ- ing the diurnal light cycle can alter sexual expression.
These are mainly volatile terpenes and sesquiterpenes. THC ratios are less likely to induce anxiety than vice versa. Synthetic THC, called dronabinol, cannabis. Re- trieved 28 May Cannabis and Cannabinoid Research 1 1: Drug Testing and Analysis 4 Journal of Industrial Hemp 8 2: Botanical Gazette 71 Retrieved 28 May Flavour and Fragrance Journal 16 4: Cannabis indica, formally known as Cannabis sativa forma indica, is an annual plant in the Cannabaceae family.
Indica strains tend to have wide, short leaves with indica. Lamarck based his description of the newly named short wide blades, whereas sativa strains have long leaves species on plant specimens collected in India. Richard with thin long blades. The buds of indica strains tend to be Evans Schultes described C.
Schultes's and Anderson's descriptions may have originated from the Hindu Kush mountain range. These are merely comparative values, we must not in- summers climate of those parts, C.
I am in a pain management program and I was told that they test for cannabiniols across the board so even though there is no THC I could still test positive and be kicked out of the program. This is so unfair because CBC has been the best thing for PTSD anxiety and depression instead they would rather me be on multiple drugs with multiple bad side effects.
Any thoughts or help on this I would greatly appreciate how to get around it. The author appears to be confused and thinks oil is contaminating the cannabinoids. They ARE oils except for those that are waxes at room temp. And that was just the third sentence. The only one I have tried is from Hemp Lucid. I bought both the water soluble oil and the cream in a local shop.
Please advise if you have any other info Thank you! As a representative with 2 companies that have CBD on the market and as a person with intractable pain and multple painful problems wirth my spine I can say that cbd does not work for everyone. It does nothing for me or for my mil who has a cancer like growth impeding her ability to swallow and has undergone radiation to shrink it. There is a tremendous difference between CBD from hemp vs the actual cannabis plant; not addressed the fact that you are discussing CBD from hemp in the beginning of the article is confusing to those who have not been able to do their own research yet.
CBD alone is beneficial in many ways to overall health as well as chronic pain, but new studies are showing that small amounts of THC, called micro-dosing, are most successful in treating severe intractable pain in addition to a low dose of an opioid pain medication! Great post and information. I for one, have bought it from a local Vape shop and researched the Co. But now you have provided me more info to make sure I buy a proper CBD.
I tried it in the winter time which is my better time of year pain wise and it did seem to help stretch the time between my med doses to an extra hour. Now, I am at my worst pain time of year summer in Fla and I am back to researching more and desperately want to give it another shot for a longer period of time. Or am I missing something in your post?? Meanwhile I will try to find it on the internet…but should I trust that?! Thank you very much!!
I tried CBD oil and it was just as useful for pain as yoga. This expensive commodity is just another catch phrase replacement theology trying to be substituted for what used to be adequate pain control treatment. Today at least my Dr stands there and says sorry as he lowers the dose by another pill. Thank you for trying. Our last ditch effort on Earth will be no doubt be to smoke MJ..
Pesticides Residual solvents from the extraction process Bacteria and fungus Foreign matter Heavy metals 5. Benefits of CO 2 Extraction: Is the Company Hiding Something? What Are They Claiming? Treat the Patient, Not the Label. I am with a company that does all you have wrote about so glad I found them. Really good article and information as I am just starting my research. Good info but looking forward to a company name that fits these criteria. Really well written about CBD oil. Apart from investing a huge amount of resources into their product lineup, it truly feels as if the team at PureKana really cares about delivering high-quality CBD therapy to suffering individuals all across the country.
I was told about CDB Oil and am really hopeful. Now to see if I can find some relief by using it. But if I was you I would stick to a reputable brand such as purekana, charlottes web or another one that has been around for a while and has good reviews.
This is really helpful and interesting. The problem with the new found popularity is that even though it is SO easy to now get hold of CBD, it is so unsafe with the amount of dodgy sellers, especially online. In the UK they have started to sell it at a good price in reputable shops, which means that at least for us in the UK it is safer.
Would CBD oil work for a person diagnosed with epilepsy?? I have complex partial seizures that can be burdensome at times. If so, which brand would be best for treatment? There is some good stuff out there… and cheap!
I need to know which brand and strength would be best for me. I started CBD gummies about 2 weeks ago. I am spend too much money on them. The package contains 7 pieces and is mg total. One package is lasting a day to a day and a half. I want to switch to oil. Would CBD oil help with my pain, and if so, how much would I need??
The oil allows me to truly relax, so I can do stretches and exercisestand stay loose enough to work. Good luck with your fusion! Witch one to buy for stumic ulcer. And were in South africa can i get. Quick delivery, every time I use premium CBD oil. What is weird is that for me it worked. For my husband it had no effect. Leslie N, some people need a higher potency due to chronic issues, others may need a full spectrum version, not just CBD isolate.
In essence, cannabinoids work better together. We just purchased some gummies in Tampa Florida and both of us has seen results in just a week. They are 10mg each. Any thoughts or practices on this? Leave a Reply Cancel reply. Your email address will not be published. Remember me Lost your password? John on February 9, June D on February 11, Shane on February 1, Will Summers on February 5,
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